Roger,   The 1907 Winchester Catalogue lists the 50-110 W.H.V. at 2150 fps. at the muzzle with a 300gr. bullet. I do not recommend you try to duplicate that velocity, I loaded my guns to 1620fps and it kicked like a 12ga shotgun but never caused any damage. I never found the 50-110 to be as accurate as other 86 calibers but it does cut a big hole. I used new B B brass, 300gr Barnes jacketed bullets, 44grs. 4198 with a thin paper wad over the powder and 1.5 sheets of toilet paper folded and rolled like a tampon as a filler. The over all length 2.72 inches. 3 inch groups at 100 yards. The filler was necessary to keep velocity to plus or minus 25fps. My Barnes bullets were .510. When I used cast bullets I sized to .509, I had leading issues; I do not use gas checks.          This is not a recommendation, this is what I did in my rifles. T/R  

  Roger, The thin paper wad is .500 in diameter, is cut out of magazine paper, and neatly placed on top of the powder.The wad keeps the powder against the primer and prevents the powder from mixing with the toilet paper. The toilet paper is neatly folded then rolled and installed on top of the wad, placing it between the wad and the bullet. The large case size of the 50-110 was designed for bulky black powder not small amounts of smokeless. Some smokeless powders if let lay loosely on their side without a filler create a shaped charge and can cause velocity variance between shots or even chamber damage. The use of fillers gives less variance of velocity. I have never had an issue with the paper, it just blows out the barrel in the from of  confetti. I also use magnum primers. I would start with a lighter load, that 110 year old figured wood looks nice but can crack in the wrist. A good book on loading for old Winchesters is “The Winchester Lever Legacy” by Clyde Williamson. He shot 750,000 rounds to gather data for his 664 page book. I read his book before I loaded my first 86 round. Clyde’s loads are hot so start light. T/R

 Roger, I have also used 3031 with TP or corn meal as filler but the 4198 and TP worked much better. TP varies in thickness, what I do is measure the distance between the wad and back of bullet when seated ,(example 1 inch), fold the sheet of TP  the long way 1 inch over and over until it is long, skinny, thick rectangle, then roll it tightly. It will look like a paper plug, (tampon), then insert in case over the paper wad. If your 1 inch measurement is not right adjust the width of the fold accordingly, if the tampon is to thick to fit the case, shorten the sheet, if to thin lengthen the sheet. It is important to use the same amount of TP in each case to keep the velocity the same. I hand weigh every charge. Do not use antique brass, used brass is not as strong as new. Wear eye protection. I used an antique balloon head case in a 40-82 once and temporarily lost my eye lashes and brows when the case head blew off, no damage to the $20,000 deluxe 86.  Be safe! T/R       

 Roger, When you increase the weight of the bullet that much you are in uncharted territory. I only shot 300gr. bullets in my guns, I do not know what you will have for chamber pressure. Roger, this is a big gun, but not indestructible. The price of the Barnes bullets is relative cheap compared to the gun. T/R